Ethylenediamine → 3-beta-Aminoethylamino-1-(benzodioxan-5-yloxy)-2-propanol

HRID 443472Notes

Reaction equation

HRID 443472 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:12][CH:13]3[O:15][CH2:14]3)[C:5]=2[O:4][CH2:3][CH2:2]1.[CH2:16]([NH2:19])[CH2:17][NH2:18]>>[NH2:18][CH2:17][CH2:16][NH:19][CH2:14][CH:13]([OH:15])[CH2:12][O:11][C:10]1[C:5]2[O:4][CH2:3][CH2:2][O:1][C:6]=2[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 3301EthylenediamineHCID 37114295-(Oxiran-2-ylmethoxy)-2,3-dihydro-1,4-benzodioxine

Product 1

HCID 130640833-beta-Aminoethylamino-1-(benzodioxan-5-yloxy)-2-propanol

Procedure

A mixture of 20.8 g. of 1-(benzodioxan-5-yloxy)-2,3-epoxypropane and 120 g. of ethylenediamine is heated at 90° C. for 18 hours and is then evaporated to dryness under reduced pressure. The residue is stirred with 100 ml. of water and the mixture is extracted four times with 100 ml. of chloroform each time. The combined chloroform extracts are dried and evaporated to dryness under reduced pressure and there is thus obtained as residue 3-β-aminoethylamino-1-(benzodioxan-5-yloxy)-2-propanol.

Workup

  1. additionA mixture of 20.8 g
  2. customis then evaporated to dryness under reduced pressure
  3. extractionof water and the mixture is extracted four times with 100 ml
  4. dry with materialThe combined chloroform extracts are dried
  5. customevaporated to dryness under reduced pressure and there

Sources & evidence

ORD record
ord-434774e1d07d4055a0e48680d809a4e5
Source dataset
uspto-grants-1981_04
Patent number
US04260632

Reaction notes

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