Phosphorus pentachloride → 17136-54-8

Participants

Reaction Steps

To a stirred suspension of 104 g of phosphorous pentachloride in 550 ml of methylene chloride at -10° C., is added 70 g of L-serine methyl ester hydrochloride, in approximately 5 g portions, over a period of 40 minutes while the temperature is maintained between -10 and 0° C. The reaction mixture is then allowed to warm to room temperature with stirring. Stirring is continued for 2-3 hours and the mixture is then poured into 550 ml of stirred petroleum ether. The resultant mixture is filtered and the filter cake is washed with petroleum ether (3×100 ml) and then with ether (2×100 ml). The combined filtrate and washings are dried under vacuum over sodium hydroxide pellets to afford 71 g of β-chloroalanine methyl ester hydrochloride.

Provenance & Evidence