Cyanamide → HCID 131712146, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 25.3 g of 1-ethyl-2-ethylaminomethylindoline hemisulphate and 25 g of cyanamide is heated at 120° C. for 20 minutes. After cooling, acetone is added and the mixture is filtered. The crystals are taken up in icecold sodium bicarbonate solution and the aqueous phase is extracted with chloroform. The oily base obtained after drying and evaporating the chloroform phase is dissolved in a little methanol and the pH of the solution is adjusted to 6 with sulphuric acid. The solution is evaporated. The residue is triturated with acetone and 1-ethyl-2-(1-ethyl-guanidinomethyl)-indoline hemisulphate is obtained, m.p. 230° C.

Provenance & Evidence