HCID 178462753, compound → HCID 178462457, compound

Participants

Reaction Steps

A solution of 26.5 g of 1-ethyl-2-guanidinomethylindole hemisulphate (obtainable from ethyl indole-2-carboxylate via ethyl 1-ethyl-indole-2-carboxylate, 1-ethyl-2-hydroxymethyl-indole, 1-ethyl-2-chloromethyl-indole, 1-ethyl-2-phthalimidomethyl-indole and 1-ethyl-2-aminomethyl-indole) in a mixture of 300 ml of acetic acid and 70 ml of 2 N sulphuric acid is hydrogenated at 60° C. with 10 g of palladium/barium sulphate (5%) under normal pressure. After the absorption of hydrogen has ceased, the solution is filtered. The filtrate is evaporated and 1-ethyl-2-guanidinomethylindoline hemisulphate is obtained, m.p. 199° C.

Provenance & Evidence