HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 5,6-dihydro-6-methyl-1,5-dioxo-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-2-carboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5,6-dihydro-1,5-dioxo-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-2-carboxylic acid, ethyl ester | HCID 86737676 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5,6-dihydro-6-methyl-1,5-dioxo-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-2-carboxylic acid, ethyl ester | HCID 86737678 | — |
Reaction Steps
5.22 g 5,6-dihydro-1,5-dioxo-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-2-carboxylic acid, ethyl ester, made as in Example 1, 2.76 g K2CO3 and 50 mM CH3I are dissolved in 100 ml dimethylformamide and stirred for 20 hours. The crystalline 5,6-dihydro-6-methyl-1,5-dioxo-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-2-carboxylic acid, ethyl ester is isolated after filtration and recrystallized from dimethylformamide/ethanol. The yield is 4.7 g as white needles with a melting point of 243°-244° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04260751 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-4b3ac266d03f43ab8bfd22f8729ba000 |
| Source note | uspto-grants-1981_04 |