Acetyl chloride → HCID 86737682, compound

HRID 443558Notes

Reaction equation

HRID 443558 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([CH2:8][C:9]([N:11](F)[N:12](F)F)=[O:10])[CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C>>[Cl:1][C:2]1[N:7]=[C:6]([CH2:8][C:9]([NH:11][NH2:12])=[O:10])[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 131712162HCID 131712162, compound

Product 1

HCID 86737682HCID 86737682, compound

Procedure

A 4.3 g. portion of 2-chloro-6-hydrazinopyridine (prepared in Example 1) is treated with acetyl chloride by the procedure of Example 2. The reaction mixture is evaporated to dryness and the solid is treated with a saturated aqueous solution of sodium bicarbonate and filtered to yield 5.33 g. of crude product. The material is recrystallized from acetone to yield 3.70 g. of the product of the Example m.p. 220°-225° C.

Workup

  1. customThe reaction mixture is evaporated to dryness
  2. additionthe solid is treated with a saturated aqueous solution of sodium bicarbonate
  3. filtrationfiltered
  4. customto yield 5.33 g
  5. customThe material is recrystallized from acetone
  6. customto yield 3.70 g

Sources & evidence

ORD record
ord-f93596d351fb4d6fb6decdcda25a7887
Source dataset
uspto-grants-1981_04
Patent number
US04260767

Reaction notes

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