Pyridine → HCID 86737684, compound

HRID 443559Notes

Reaction equation

HRID 443559 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([CH2:8][C:9]([N:11](F)[N:12](F)F)=[O:10])[CH:5]=[CH:4][CH:3]=1.N1C=CC=CC=1.[Cl:22]CC(Cl)=O>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[C:6]([CH:8]([Cl:22])[C:9]([NH:11][NH2:12])=[O:10])[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 6577Chloroacetyl chlorideHCID 131712162HCID 131712162, compound

Product 1

HCID 86737684HCID 86737684, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 3.0 g. of 2-chloro-6-hydrazinopyridine (prepared in Example 1), 1.7 g. of pyridine and 35 ml. of methylene chloride is treated with 2.5 g. of chloroacetyl chloride according to the procedure of Example 2. The reaction mixture is stirred for one hour, then is filtered and washed with methylene chloride to collect 2.3 g. of colorless solid. The solid is recrystallized from tetrahydrofuran-hexane to give the product of the Example m.p. 176°-177° C.

Workup

  1. additionA mixture of 3.0 g
  2. filtrationis filtered
  3. washwashed with methylene chloride
  4. customto collect 2.3 g
  5. customThe solid is recrystallized from tetrahydrofuran-hexane
  6. customto give the product of the Example m.p. 176°-177° C.

Sources & evidence

ORD record
ord-6b12aefddc744c468e7f64f5ecf50738
Source dataset
uspto-grants-1981_04
Patent number
US04260767

Reaction notes

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