Benzoyl isocyanate → N-((3-Cyano-4,5-dimethylthiophen-2-yl)(ethyl)carbamoyl)benzamide

HRID 44356Notes

Reaction equation

[CH2:1]([NH:3][C:4]1[S:5][C:6]([CH3:12])=[C:7]([CH3:11])[C:8]=1[C:9]#[N:10])[CH3:2].[C:13]([N:21]=[C:22]=[O:23])(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:9]([C:8]1[C:7]([CH3:11])=[C:6]([CH3:12])[S:5][C:4]=1[N:3]([CH2:1][CH3:2])[C:22]([NH:21][C:13](=[O:20])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:23])#[N:10]

Participants

Reactant 2

HCID 78210Benzoyl isocyanate

HCID 574569162-(Ethylamino)-4,5-dimethylthiophene-3-carbonitrile

Product 1

HCID 67097966N-((3-Cyano-4,5-dimethylthiophen-2-yl)(ethyl)carbamoyl)benzamide

Procedure

Prepared in a similar manner to Example 1a from 2-(ethylamino)-4,5-dimethylthiophene-3-carbonitrile (Example 21b) and benzoyl isocyanate. MS 328 (MH+).

Sources & evidence

ORD record: ord-02f3e18b5ac144fdb077f9105965bcb6
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08541421B2

Reaction notes

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