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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 443570Generated: October 29, 2026

Cyanogen Bromide → HCID 23467856, compound

https://huagongshe.com/reaction/443570

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyanogen BromideHCID 10476—
ReactantPotassium HydroxideHCID 14797—
ReactantHCID 13193920HCID 13193920—
SolventEthylene GlycolHCID 174—
SolventDichloromethaneHCID 6344—
ProductHCID 23467856HCID 23467856—

Reaction Steps

Thus, 9-methoxy-3-methyl-2,3,4,4a,5,6,7,7a-octahydro-1H-benzo[4,5]furo[3,2-e]isoquinoline (Example 2d) is heated to reflux with cyanogen bromide in methylene chloride and the crude product is then heated with potassium hydroxide in ethylene glycol to 170° to give 9-methoxy-2,3,4,4a,5,6,7,7a-octahydro-1H-benzo[4,5]furo[3,2-e]isoquinoline (R1 =H; R2 =OMe; R3, R4, R5 =H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04260761
Source datasetuspto-grants-1981_04
ORD IDord-0a1ad1f6f6a549819c0cc499c55b9c0e
Source noteuspto-grants-1981_04