HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 5-Chloro-2'-fluoro-2-iodobenzhydrol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | (5-Chloro-2-iodophenyl)(2-fluorophenyl)methanone | HCID 12948263 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Chloro-2'-fluoro-2-iodobenzhydrol | HCID 20563122 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
A mixture of 54 g (0.15 mole) of 5-chloro-2'-fluoro-2-iodobenzophenone and 28.4 g (0.75 mole) of sodium borohydride in 1000 ml of ethanol was stirred at 0° C. for 15 min. The solution was diluted with water and extracted with ether. The ether solution was washed with water, dried over anhydrous sodium sulfate, and concentrated at reduced pressure to give a deep yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04260772 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-8f621fad600a4216a978b8e01061c24f |
| Source note | uspto-grants-1981_04 |