Benzoyl isocyanate → N-((3-Cyano-4,5-dimethylthiophen-2-yl)(methyl)carbamoyl)-benzamide

HRID 44358Notes

Reaction equation

[CH3:1][C:2]1[C:3]([C:10]#[N:11])=[C:4]([NH:8][CH3:9])[S:5][C:6]=1[CH3:7].[C:12]([N:20]=[C:21]=[O:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:10]([C:3]1[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][C:4]=1[N:8]([CH3:9])[C:21]([NH:20][C:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:22])#[N:11]

Participants

Reactant 2

HCID 78210Benzoyl isocyanate

HCID 574569174,5-Dimethyl-2-(methylamino)thiophene-3-carbonitrile

Product 1

HCID 67096977N-((3-Cyano-4,5-dimethylthiophen-2-yl)(methyl)carbamoyl)-benzamide

Procedure

Prepared as in Example 1a from 4,5-dimethyl-2-(methylamino)thiophene-3-carbonitrile (Example 22b) and benzoyl isocyanate. MS 314 (MH+).

Sources & evidence

ORD record: ord-e54f57cde3e04d3b9d3389d825d65e01
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08541421B2

Reaction notes

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