反应详情

To a suspension of 5.084 g of 4-carbamoyl-imidazolium-5-olate in 104 ml of dry pyridine was added 11.41 g of p-bromobenzoyl chloride at room temperature. After addition was over, the mixture was stirred at 40°-45° C. for 2.5 hours. The separated crystals were filtered off, washed with chloroform and diisopropyl ether, dried under vacuum to give 10.535 g of 5-carbamoyl-1H-imidazol-4-yl p-bromobenzoate, m.p. 232°-233° C. (dec.)

1. additionAfter addition
2. filtrationThe separated crystals were filtered off
3. washwashed with chloroform and diisopropyl ether
4. customdried under vacuum