反应详情

A solution of 18.2 g of 2,3-dihydro-2-oxo-benzo[b]thiophene in 60 ml of hexamethylphosphoric acid triamide is added dropwise to a suspension of 5.9 g of a 50% strength sodium hydride/mineral oil suspension in 180 ml of hexamethylphosphoric acid triamide whilst cooling, the reaction temperature being kept below 15°. After stirring for one hour at room temperature, 30.4 g of phenyl N-(3-chlorophenyl)-carbamate are added in portions, with external cooling. The mixture is stirred for a further 16 hours at room temperature and poured onto a mixture of 100 ml of 2 N hydrochloric acid and 1,000 g of ice, whereupon an oil separates out; this oil crystallises on leaving to stand for several hours. The crystals are collected and dissolved in 300 ml of diethyl ether. The solution is washed with water and the organic phase is separated off, dried over sodium sulphate and evaporated to dryness. The residue is recrystallised from ether and gives N-(3-chlorophenyl)-2-oxo-2,3-dihydro-3-benzo[b]thiophenecarboxamide with a melting point of 175°-177°.

1. temperaturewhilst cooling
2. custombeing kept below 15°
3. stirringThe mixture is stirred for a further 16 hours at room temperature
4. customthis oil crystallises
5. customon leaving
6. waitto stand for several hours
7. customThe crystals are collected
8. dissolutiondissolved in 300 ml of diethyl ether
9. washThe solution is washed with water
10. customthe organic phase is separated off
11. dry with materialdried over sodium sulphate
12. customevaporated to dryness
13. customThe residue is recrystallised from ether