Benzocaine → HCID 23468284, compound

Participants

Reaction Steps

A solution of 10.0 g. of 6-(2-naphthyloxy)-1-hexanol O-methanesulfonate and 9.7 g. of ethyl 4-aminobenzoate in 50 ml. of hexamethylphosphoramide is heated at 110° C. for 16 hours. The solution is cooled, diluted with water, filtered and the solid washed with ethanol and water to give 7.7 g. of product. Recrystallization from ethanol and once from acetone-hexane gives crystals, m.p. 109°-110° C.

Provenance & Evidence