反应详情

A solution of 10 g. 3-(α-naphthyloxy)propyl bromide and 12.5 g. ethyl 4-aminobenzoate in 100 ml. hexamethylphosphoramide is stirred at 110° for 15 hours. The cooled solution is diluted with 200 ml. water and extracted 3 times with 100 ml. portions of ether. The combined extracts are washed with brine, dried and evaporated to an orange residue. The product is crystallized from ethanol to yield a solid which is crystallized from ethanol to yield white crystals, m.p. 93°-94° C.

1. additionThe cooled solution is diluted with 200 ml
2. extractionwater and extracted 3 times with 100 ml
3. washThe combined extracts are washed with brine
4. customdried
5. customevaporated to an orange residue
6. customThe product is crystallized from ethanol
7. customto yield a solid which
8. customis crystallized from ethanol
9. customto yield white crystals, m.p. 93°-94° C.