Dichloromethane → HCID 23468304, compound

Participants

Reaction Steps

To a solution of 5.4 g. of ethyl 4-[N-trifluoroacetyl-2-(1-naphthyloxy)ethylamino]benzoate and 1.5 g. of cyanogen bromide in 200 ml. of methylene chloride at -5° C. is added 5.7 g. of anhydrous aluminum chloride. The solution is allowed to stand at room temperature for 5 hours and then poured into 200 ml. of ice and water. After addition of 20 ml. of concentrated hydrochloric acid, the organic layer is seperated, washed with water, dried and evaporated to dryness. Recrystallization from 75% aqueous acetonitrile gives material, m.p. 150°-151° C.

Provenance & Evidence