Hydrochloric Acid → HCID 23468278, compound

Participants

Reaction Steps

To a solution of 5.4 g. of ethyl 4-[N-trifluoroacetyl-2-(1-naphthyloxy)ethylamino]benzoate and 5.7 g. of anhydrous aluminum chloride at 0° C. is added 1.1 g. of acetyl chloride with stirring. After 1 hour at 0° C., the solution is poured over 200 g. of ice plus 20 ml. concentrated hydrochloric acid. The organic phase is separated and the aqueous phase re-extracted. After washing with dilute acid, the methylene chloride extract is evaporated to dryness. The residue is crystallized from acetonitrile, m.p. 160°-161° C.

Provenance & Evidence