HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → Ethyl 4-[2-(1,2,3,4-tetrahydro-5-naphthyloxy)ethylamino]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 5,6,7,8-Tetrahydro-1-naphthol | HCID 68258 | — |
| Reactant | Ethyl 4-(2-bromoethylamino)benzoate | HCID 23468291 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | Ethyl 4-[2-(1,2,3,4-tetrahydro-5-naphthyloxy)ethylamino]benzoate | HCID 23468308 | — |
Reaction Steps
To a slurry of 2.3 g. of 57% sodium hydride-in-oil (previously washed free of oil with hexane) in 20 ml. of dimethoxyethane is added 7.4 g. of 1,2,3,4-tetrahydro-5-naphthol in 20 ml. of dimethoxyethane and then 13.6 g. of ethyl 4-(2-bromoethylamino)benzoate. After refluxing for 6 hours and dilution with 300 ml. of water, the solid is collected and recrystallized from acetonitrile, m.p. 133°-135° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04260816 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-0f9d53abd0f442ee8124995903aa692c |
| Source note | uspto-grants-1981_04 |