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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 44370Generated: October 26, 2026

Methylamine → 2-chloro-N-methylquinazolin-4-amine

https://huagongshe.com/reaction/44370

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethylamineHCID 6329—
Reactant2,4-DichloroquinazolineHCID 252886—
Product2-chloro-N-methylquinazolin-4-amineHCID 318057—

Reaction Steps

Prepared as in Example 38 from 2,4-dichloroquinazoline and methylamine. 1H NMR (400 MHz, DMSO-d6) δ2.98 (d, J=4.4 Hz, 3H), 7.53-7.49 (m, 1H), 7.61-7.58 (m, 1H), 7.79-7.75 (m, 1H), 88.19-8.17 (m, 1H), 78 (bs, 1H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08541421B2
Source datasetuspto-grants-2013_09
ORD IDord-e4821d3fbc3c4b5bad61e6c4bed39fac
Source noteuspto-grants-2013_09