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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 443712Generated: October 30, 2026

Hexane → 3-(3-Methylphenyl)-1,2-thiazole-4-carboxylic acid

https://huagongshe.com/reaction/443712

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHexaneHCID 8058—
Reactant3-(m-Tolyl)-4,5-Isothiazoledicarboxylic AcidHCID 12437431—
Solvent1,2-DichlorobenzeneHCID 7239—
Product3-(3-Methylphenyl)-1,2-thiazole-4-carboxylic acidHCID 1243744985.1%

Reaction Steps

3-(m-Tolyl)-4,5-isothiazoledicarboxylic acid (7.98 g, 0.0303 mol) was heated in 25 ml of o-dichlorobenzene at vigorous reflux for 15 minutes and cooled. Hexane was added and the resultant precipitate was filtered off to yield 5.52 g (0.0258 mol, 83.1%) of a light pink solid, m.p. 144.5°-146°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04261728
Source datasetuspto-grants-1981_04
ORD IDord-846e8e690d79417ea61231af49d6a67c
Source noteuspto-grants-1981_04