HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 443774Generated: October 29, 2026
Water → N-(1,3-thiazol-2-yl)-4-nitro-2-trichloromethylphenylsulfenamide
https://huagongshe.com/reaction/443774
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 4-Nitro-2-trichloromethylbenzenesulfenyl chloride | HCID 12763555 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(1,3-thiazol-2-yl)-4-nitro-2-trichloromethylphenylsulfenamide | HCID 23465398 | 70% |
Reaction Steps
40 g of 2-aminothiazole is dissolved in 500 ml of tetrahydrofuran; while stirring and at 10° C., 61.4 g of 4-nitro-2-trichloromethylbenzenesulfenyl chloride is added. The addition of water precipitates the sulfenamide, which is filtered and recrystallized from ethyl acetate. There is obtained 50 g (70% of theory) of N-(1,3-thiazol-2-yl)-4-nitro-2-trichloromethylphenylsulfenamide; m.p.: 165° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04261924 |
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| Source dataset | uspto-grants-1981_04 |
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| ORD ID | ord-8639666210024c48959d2c2918f0497a |
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| Source note | uspto-grants-1981_04 |
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