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Ethyl ketone → N-(1-ethylpropyl)-3,4-dimethylaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl ketone | HCID 7288 | — |
| 反応物 | 4-Nitro-o-xylene | HCID 7440 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Platinum | HCID 23939 | — |
| 触媒 | Naphthalene-2-sulfonic acid--water (1/1) | HCID 20499058 | — |
| 生成物 | N-(1-ethylpropyl)-3,4-dimethylaniline | HCID 91984 | 99.8% |
反応手順
A mixture of 151 grams (1.0 mole) 4-nitro-o-xylene, 138 grams (1.6 moles) diethyl ketone, 5.8 grams of 5% platinum on carbon and 3.7 grams of 2-naphthalenesulfonic acid monohydrate were added to a pressure vessel. Hydrogen was fed into the reactor at a pressure of 30-40 psi and a temperature of 80°-100° C. When hydrogen uptake ceased, the vessel was cooled and vented. After filtering the catalyst, the aqueous phase was separated and the upper layer concentrated in vacuo to give 191 grams of 96% pure N-(1-ethylpropyl)-3,4-xylidine (96% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04261926 |
| 出典データセット | uspto-grants-1981_04 |
| ORD ID | ord-57096514b3cc4ab5a08feee813577c3d |
| 出典メモ | uspto-grants-1981_04 |