反应详情

13.6 g (0.1 mol) of 2-cyclopropyl-4-hydroxy-pyrimidine were added to a solution of 5.6 g (0.1 mol) of potassium hydroxide in 100 ml of water. 16 g (0.1 mol) of bromine were then added dropwise at 15°-20° C., with slight cooling, and the mixture was stirred for a further hour at room temperature. The product which had precipitated was filtered off and rinsed with water. 15 g (70% of theory) of 2-cyclopropyl-4-hydroxy-5-bromo-pyrimidine were thus obtained in the form of colorless crystals of melting point 200° C.

1. customThe product which had precipitated
2. filtrationwas filtered off
3. washrinsed with water