Potassium Hydroxide → HCID 178517403, compound

HRID 443788Notes

Reaction equation

HRID 443788 reaction equation
[CH:1]1([C:4]2[N:9]=[C:8]([OH:10])[CH:7]=[CH:6][N:5]=2)[CH2:3][CH2:2]1.[OH-].[K+].[Br:13]Br>O>[CH:1]1([C:4]2[N:9]=[C:8]([OH:10])[C:7]([Br:13])=[CH:6][N:5]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 24408BromineHCID 1785164792-Cyclopropylpyrimidin-4-ol

Product 1

HCID 178517403HCID 178517403, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

13.6 g (0.1 mol) of 2-cyclopropyl-4-hydroxy-pyrimidine were added to a solution of 5.6 g (0.1 mol) of potassium hydroxide in 100 ml of water. 16 g (0.1 mol) of bromine were then added dropwise at 15°-20° C., with slight cooling, and the mixture was stirred for a further hour at room temperature. The product which had precipitated was filtered off and rinsed with water. 15 g (70% of theory) of 2-cyclopropyl-4-hydroxy-5-bromo-pyrimidine were thus obtained in the form of colorless crystals of melting point 200° C.

Workup

  1. customThe product which had precipitated
  2. filtrationwas filtered off
  3. washrinsed with water

Sources & evidence

ORD record
ord-b5ac841e3e01432687b061bc94dbc287
Source dataset
uspto-grants-1981_04
Patent number
US04261983

Reaction notes

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