反应详情

The starting material is prepared as follows: The mixture 268 of diphenylmethanol, 200 g of 4-hydroxypiperidine hydrochloride and 28.8 g of p-toulenesulfonic acid monohydrate is stirred and heated to 160° while reducing the pressure to 0.2 mm Hg with a vacuum pump for 3 hours. It is cooled to 80°, dissolved in 500 ml of ethanol and the solution cooled to 10°. The resulting suspension is filtered, the residue washed with isopropanol and dried at 60°, to yield the 4-diphenylmethoxy-piperidine hydrochloride. It is suspended in 1,800 ml of water, converted into the free base with 125 ml of aqueous ammonia and extracted with diethyl ether and the extract evaporated.

1. customThe starting material is prepared
2. temperatureheated to 160°
3. customfor 3 hours
4. temperatureIt is cooled to 80°
5. temperaturethe solution cooled to 10°
6. filtrationThe resulting suspension is filtered
7. washthe residue washed with isopropanol
8. customdried at 60°