1,2,4-Oxadiazol-3-amine, 5-((2,6-dichlorophenyl)methyl)- → HCID 54050783, compound

HRID 443805Notes

Reaction equation

HRID 443805 reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([CH2:7][C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:15])[O:4][N:3]=1.[CH:16]([O-])([O-])[O:17][CH2:18][CH3:19]>>[CH2:18]([O:17][CH:16]=[N:1][C:2]1[N:6]=[C:5]([CH2:7][C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:15])[O:4][N:3]=1)[CH3:19]

Participants

3

Reactant 2

HCID 27431271,2,4-Oxadiazol-3-amine, 5-((2,6-dichlorophenyl)methyl)-HCID 53630039Ethylorthoformate2×

Product 1

HCID 54050783HCID 54050783, compound

Procedure

1 g of 3-amino-5-(2,6-dichlorobenzyl)-1,2,4-oxadiazole is heated in air at 150° C. for 3 hours with a few ml of ethyl orthoformate in an amount which is just sufficient to ensure slight agitation. The excess ethyl orthoformate is driven off under reduced pressure. The residue is crystallised from ether.

Workup

  1. customThe residue is crystallised from ether

Sources & evidence

ORD record
ord-95b8396018b64d9fbba036c0cc3396ee
Source dataset
uspto-grants-1981_04
Patent number
US04261994

Reaction notes

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