HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Hydroxyethyl)indoline → (RS)-2-(2-Hydroxyethyl)-N-(3-methylisoquinol-5-yl)indoline-1-carbothioamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Hydroxyethyl)indoline | HCID 13014319 | — |
| Reactant | 5-Isothiocyanato-3-methylisoquinoline | HCID 13014321 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (RS)-2-(2-Hydroxyethyl)-N-(3-methylisoquinol-5-yl)indoline-1-carbothioamide | HCID 13014324 | 54% |
Reaction Steps
2-(2-Hydroxyethyl)indoline (43 g) and 5-isothiocyanato-3-methylisoquinoline (52 g) are dissolved in ethanol (800 cc). The solution, which is kept for 24 hours at a temperature of about 20° C., deposits a solid which is isolated by filtration, washed with ethanol (3×50 cc) and dried. (RS)-2-(2-Hydroxyethyl)-N-(3-methylisoquinol-5-yl)indoline-1-carbothioamide (51 g), a white solid, is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04261993 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-7f0b1f16aab8485aa9786e837a80ea9c |
| Source note | uspto-grants-1981_04 |