反应详情

A catalyst (3% palladium-on-charcoal; 8 g) is added to a solution of 3-methoxymethyl-5-nitroisoquinoline (78 g) in ethanol (2 liters). The resulting suspension is stirred and hydrogen is bubbled through for 6 hours, whilst keeping the temperature between 20° and 25° C. with the aid of a cold-water bath. The reaction mixture is filtered and the filtrate is evaporated to dryness at 60° C. under reduced pressure (20 mm Hg). The residue is recrystallised from diisopropyl ether (500 cc). 5-Amino-3-methoxymethylisoquinoline (47 g), m.p. 105° C., is obtained.

1. customhydrogen is bubbled through for 6 hours
2. customthe temperature between 20° and 25° C.
3. filtrationThe reaction mixture is filtered
4. customthe filtrate is evaporated to dryness at 60° C. under reduced pressure (20 mm Hg)
5. customThe residue is recrystallised from diisopropyl ether (500 cc)