反应详情

温度

20 °C

A mixture of 3-chloromethylisoquinoline hydrochloride (96 g) and sodium methoxide (80 g) in methanol (1.5 liters) is heated under reflux for 8 hours. After cooling to 20° C., the mixture is filtered and the filtrate is evaporated to dryness at 50° C. under reduced pressure (20 mm Hg). The residue is taken up in methylene chloride (1 liter), the mixture is washed with water (3×150 cc), the organic phase is dried over magnesium sulphate and filtered, and the filtrate is evaporated to dryness at 40° C. under reduced pressure (20 mm Hg). The oily residue is distilled at 82° C. under reduced pressure (0.6 mm Hg). 3-Methoxymethylisoquinoline (68 g), a colourless oil, is obtained.

1. temperatureis heated
2. temperatureunder reflux for 8 hours
3. filtrationthe mixture is filtered
4. customthe filtrate is evaporated to dryness at 50° C. under reduced pressure (20 mm Hg)
5. washthe mixture is washed with water (3×150 cc)
6. dry with materialthe organic phase is dried over magnesium sulphate
7. filtrationfiltered
8. customthe filtrate is evaporated to dryness at 40° C. under reduced pressure (20 mm Hg)
9. distillationThe oily residue is distilled at 82° C. under reduced pressure (0.6 mm Hg)