反应详情

温度

5 °C

3-Hydroxymethylisoquinoline (110 g) is added to thionyl chloride (130 cc), whilst cooling so as to keep the temperature between 25° and 30° C. The reaction mixture is then heated to the reflux temperature at a rate which is such that the evolution of gas is not excessive. The mixture is heated under reflux for 90 minutes (until the evolution of gas ceases) and then for a further 30 minutes. It is then cooled to 5° C. with ice, the slurry formed is filtered and the solid is washed with diethyl ether. 3 -Chloromethylisoquinoline hydrochloride (136 g), m.p. 202° C., is obtained.

1. temperaturewhilst cooling so as
2. customthe temperature between 25° and 30° C
3. temperatureThe reaction mixture is then heated to the reflux temperature at a rate which
4. temperatureThe mixture is heated
5. temperatureunder reflux for 90 minutes (until the evolution of gas ceases) and then for a further 30 minutes
6. customthe slurry formed
7. filtrationis filtered
8. washthe solid is washed with diethyl ether