Sodium Hydroxide → HCID 178455548, compound

HRID 443825Notes

Reaction equation

HRID 443825 reaction equation
[CH2:1]([S:5][C:6]1[CH:15]=[CH:14][C:13]2[NH:12][C:11]3=[CH:16][C:17]([C:19]([OH:21])=[O:20])=[N:18][N:10]3[C:9](=[O:22])[C:8]=2[CH:7]=1)[CH2:2][CH2:3][CH3:4].[OH-:23].[Na+]>O>[OH2:20].[CH2:1]([S:5]([C:6]1[CH:15]=[CH:14][C:13]2[NH:12][C:11]3=[CH:16][C:17]([C:19]([OH:21])=[O:20])=[N:18][N:10]3[C:9](=[O:22])[C:8]=2[CH:7]=1)=[O:23])[CH2:2][CH2:3][CH3:4].[CH2:1]([S:5]([C:6]1[CH:15]=[CH:14][C:13]2[NH:12][C:11]3=[CH:16][C:17]([C:19]([OH:21])=[O:20])=[N:18][N:10]3[C:9](=[O:22])[C:8]=2[CH:7]=1)=[O:23])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178454933HCID 178454933, compound

Product 1

HCID 178455548HCID 178455548, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

From 4,9-dihydro-7-(butylthio)-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid (3.17 g, 10 mmole), 1(N) NaOH soln (10 ml) in water (150 ml) and NaIO4 (2.14 g; 10 mmole) in water (50 ml); following the procedure of Example 7, there is obtained 4,9-dihydro-7-(butylsulfinyl)-9-oxo-pyrazolo[5,1-b]-quinazoline-2-carboxylic acid, hemihydrate (2.0 g); mp 205°-210° (d) remelts at 260° (d) after crystallization from aq. methanol.

Sources & evidence

ORD record
ord-9596cd9d3c1f4dc7826a9171c189265b
Source dataset
uspto-grants-1981_04
Patent number
US04261996

Reaction notes

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