HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Methylsulfanyl)-2-nitrobenzoic acid → 2-Amino-5-(methylsulfanyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Methylsulfanyl)-2-nitrobenzoic acid | HCID 8934576 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-5-(methylsulfanyl)benzoic acid | HCID 12713252 | — |
Reaction Steps
A mixture of 5-methylthio-2-nitrobenzoic acid (25.4 g; 0.119 mole), methanol (200 ml) and Raney nickel (2 g) is shaken in an atmosphere of hydrogen at 50 lb pressure when theoretical amount of hydrogen is absorbed. The catalyst is filtered off and the filtrate evaporated to dryness. The residue is recrystallized from etheriso-Pr2O. Yield 7.6 g; mp 145°-150°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04261996 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-b25cfef8cded444f874966915cfbe930 |
| Source note | uspto-grants-1981_04 |