反应详情

5-Isothiocyanato-3-methylisoquinoline (5.1 g) is added to a solution of (RS)-6-hydroxymethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (3.4 g) in absolute ethanol (55 cc). After 15 hours at a temperature of about 20° C., the resulting crystals are filtered off, washed with diisopropyl ether and then dried at 60° C. under reduced pressure (0.1 mm Hg; 0.013 kPa). (RS)-6-Hydroxymethyl-5-[(3-methylisoquinol-5-yl)thiocarbamoyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (6.9 g), melting at 190° C., is thus obtained.

1. filtrationthe resulting crystals are filtered off
2. washwashed with diisopropyl ether
3. customdried at 60° C. under reduced pressure (0.1 mm Hg; 0.013 kPa)