Pinacolone → 4,4-Dimethyl-1-(3-pyridinyl)-1-penten-3-one

Participants

Reaction Steps

100 ml of 10% strength sodium hydroxide solution were added to a solution of 35 g (0.35 mol) of 3,3-dimethylbutan-2-one and 38 g (0.355 mol) of 3-pyridinealdehyde in 2,000 ml of water and the solution was stirred overnight at room temperature. The crystalline precipitate was filtered off, dried and recrystallized from n-hexane. 34.1 g (51.5% of theory) of 4,4-dimethyl-1-pyridin-3-yl-1-penten-3-one of melting point 68°-70° C. were obtained. ##STR117##

Provenance & Evidence