Bromine → HCID 23465925, compound

Participants

Reaction Steps

320.5 g (1.676 mol) of 4,4-dimethyl-1-pyridin-3-yl-pentan-3-one were dissolved in 320 ml of aqueous 48% strength hydrobromic acid, and 267.8 g (85.3 ml; 1.65 mol) of bromine were added dropwise at 80° to 95° C. in the course of 2 hours. When the addition had ended, the solution was cooled and concentrated. The solid which remained was comminuted well, stirred with about 1.5 liters of ethanol, filtered off, washed with ethanol and dried. 450 g (78% of theory) of 2-bromo-4,4-dimethyl-1-pyridin-3-yl-pentan-3-one of melting point 163°-64° C. were obtained. ##STR119##

Provenance & Evidence