Sodium Hydroxide → HCID 12724767, compound

HRID 443854Notes

Reaction equation

HRID 443854 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7]3=[CH:13][C:14]([C:16]([O:18]CC)=[O:17])=[N:15][N:6]3[C:5](=[O:21])[C:4]=2[CH:3]=1.[OH-].[Na+]>CO>[F:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7]3=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[N:15][N:6]3[C:5](=[O:21])[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12713232HCID 12713232, compound

Product 1

HCID 12724767HCID 12724767, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

From 3.5 g of 7-fluoro-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid, ethyl ester, 50 ml of 1 N aqueous sodium hydroxide and 175 ml of methanol, following the procedure of Example 14, there is obtained 7fluoro-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid; mp 295° C., after crystallization from dimethylformamide/methanol.

Sources & evidence

ORD record
ord-4b6eceecc7d24e54a0132451206a8d12
Source dataset
uspto-grants-1981_04
Patent number
US04261997

Reaction notes

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