Sodium Hydroxide → HCID 12724765, compound

HRID 443855Notes

Reaction equation

HRID 443855 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]([CH2:12][CH3:13])[C:7]3=[CH:14][C:15]([C:17]([O:19]CC)=[O:18])=[N:16][N:6]3[C:5](=[O:22])[C:4]=2[CH:3]=1.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]([CH2:12][CH3:13])[C:7]3=[CH:14][C:15]([C:17]([OH:19])=[O:18])=[N:16][N:6]3[C:5](=[O:22])[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12713234HCID 12713234, compound

Product 1

HCID 12724765HCID 12724765, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

From 11.2 g of 7-chloro-4-ethyl-4,9-dihydro-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid, ethyl ester, 100 ml of 1 N aqueous sodium hydroxide and 250 ml of methanol, following the procedure of Example 14, there if obtained 7-chloro-4-ethyl-4,9-dihydro-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid; mp 267°-268° C. (d), after crystallization from dimethylformamide/methanol.

Sources & evidence

ORD record
ord-8e41bd1885e24c44b24de5bc678fc361
Source dataset
uspto-grants-1981_04
Patent number
US04261997

Reaction notes

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