Thionyl Chloride → HCID 12724789, compound

Participants

Reaction Conditions

Reaction Steps

Thionyl chloride (1.5 ml) is added slowly, with stirring to 50 ml of dimethylformamide at 0° C. To this solution is added 2.9 g of 4,9-dihydro-7-methoxy-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxamide and the mixture is stirred and heated at 50° C. for 18 hrs, then evaporated at reduced pressure. The residue is stirred with 600 ml of ice water and the resulting solid 4,9-dihydro-7-methoxy-4-methyl-9-oxo-pyrazolo-[5,1-b]quinazoline-2-carbonitrile is collected by filtration, washed with water and dried; mp 316°-320° C. after crystallization from dimethylformamide/ethanol.

Provenance & Evidence