Methyl [[(methoxycarbonyl)amino](methylthio)methylene]carbamate → Carbamic acid, (1,4,5,6-tetrahydro-5-(3-methoxyphenyl)-2-pyrimidinyl)-, methyl ester

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Reaction Steps

A solution of 2.61 g (14.5 m. mole) of 2-(3-methoxyphenyl)-1,3-propanediamine in 200 ml of methanol is combined with a solution of 3.0 g (14.55 m. mole) of 1,3-bis(methoxycarbonyl)-S-methylisothiourea in 200 ml of methanol and allowed to stand at room temperature over night. The crystalline product which separates is collected, washed with methanol and dried at 78° under vacuum to give 2.62 g of 2-methoxycarbonylamino-5-(3-methoxyphenyl)-1,4,5,6-tetrahydropyrimidine, mp 218°-221°.

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