Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | HCID 12891882 | HCID 12891882 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 12891912 | HCID 12891912 | — |
Reaction Steps
A mixture of 6 parts of N-(5-benzoyl-2-chlorophenyl)N'-(2-hydroxyethyl)thiourea, 2.5 parts of sodium hydride dispersion 75% and 90 parts of N,N-dimethylacetamide is stirred and heated quickly to 130° C. The reaction mixture is cooled, water is added and the whole is allowed to stand overnight. The precipitated product is filtered off, washed with water and crystallized from ethanol, yielding 2.8 parts of {2-[(2-hydroxyethyl)amino]-5-benzothiazolyl}phenylmethanone; mp. 159° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04262004 |
|---|
| Source dataset | uspto-grants-1981_04 |
|---|
| ORD ID | ord-ffeef75e443741e68b5ef2e4e7705114 |
|---|
| Source note | uspto-grants-1981_04 |
|---|
