Sulfuric acid magnesium salt (1:1) → HCID 20530959, compound

HRID 443910Notes

Reaction equation

HRID 443910 reaction equation
[CH2:1]([O:8][CH:9]([CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH2:10][CH2:11][N:12]1[C:16](=[O:17])[CH:15](C(OCC)=O)[C:14](=[O:23])[CH:13]1[CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S([O-])([O-])(=O)=O.[Mg+2]>CCOCC>[CH2:1]([O:8][CH:9]([CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH2:10][CH2:11][N:12]1[C:16](=[O:17])[CH2:15][C:14](=[O:23])[CH:13]1[CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 20530967HCID 20530967, compound

Product 1

HCID 20530959HCID 20530959, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The solution of 1-(3'-benzyloxy-n-octyl)-4-ethoxycarbonyl-2-(ethoxycarbonylmethyl)-pyrrolidin-3,5-dione in ether (obtained as described above) was stirred overnight in the presence of magnesium sulphate. The mixture was filtered and the filtrate was evaporated in vacuo giving 1-(3'-benzyloxy-n-octyl)-2-(ethoxycarbonylmethyl)-pyrrolidin-3,5-dione [71 g., 95% overall yield for steps (b) and (c)] as a yellow oil.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-4a2e179730ec4b33be228b69b6bcae73
Source dataset
uspto-grants-1981_04
Patent number
US04262008

Reaction notes

Loading…