Ethyl 3-ethoxy-3-iminopropionate hydrochloride → Ethyl 2-carbamoylacetate
Reaction equation
Cl.C([O:4][C:5](=[NH:12])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])C>CC(C)=O>[C:7]([CH2:6][C:5]([NH2:12])=[O:4])([O:9][CH2:10][CH3:11])=[O:8]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 110 °C
Procedure
200 g of ethyl β-ethoxy-β-iminopropionate hydrochloride were placed into a 1,000 ml flask and heated at 110° C. on an oil bath for 2 hours. The reaction mixture was redissolved with 500 ml of acetone, filtered by washing on the filter with other solvent. The filtrate was dried under vacuum and the obtained oily residue was grinded in 1,500 ml of ethyl ether. 108 g of a crystalline product were obtained. Upon TLC analysis, the product proved to be pure.
Workup
- filtrationfiltered
- washby washing on the
- filtrationfilter with other solvent
- customThe filtrate was dried under vacuum
- customthe obtained oily residue was grinded in 1,500 ml of ethyl ether
Sources & evidence
- ORD record
- ord-46473acf7d9f4b60be219f79698eddc5
- Source dataset
- uspto-grants-1981_04
- Patent number
- US04262087
Reaction notes
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