1,3-Dichloroacetone → HCID 86736622, compound

HRID 444007Notes

Reaction equation

HRID 444007 reaction equation
[Cl:1][CH2:2][C:3]([CH2:5]Cl)=O.[CH2:7]([NH:11][C:12]([NH:14][C:15]([NH2:17])=[S:16])=[NH:13])[CH2:8][CH2:9][CH3:10]>CC(C)=O>[ClH:1].[CH2:7]([N:11]=[C:12]([NH2:13])[NH:14][C:15]1[S:16][CH:5]=[C:3]([CH2:2][Cl:1])[N:17]=1)[CH2:8][CH2:9][CH3:10]

Participants

4

Reactant 2

HCID 107931,3-DichloroacetoneHCID 178449223HCID 178449223, compound

Product 1

HCID 86736622HCID 86736622, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

A solution of 1,3-dichloroacetone (3.02 g.) in acetone (10 ml.) was added to a stirred suspension of (N-n-butylamidino)thiourea (4.04 g.) in acetone (25 ml.) at room temperature. The resulting clear pale yellow solution was stirred for three days, then cooled in ice, and the precipitated solid filtered off and washed with acetone to give 2-(2-n-butylguanidino)-4-chloromethylthiazole hydrochloride.

Workup

  1. temperaturecooled in ice
  2. filtrationthe precipitated solid filtered off
  3. washwashed with acetone

Sources & evidence

ORD record
ord-84086ea8dd454f728c4a0af36eb519fc
Source dataset
uspto-grants-1981_04
Patent number
US04262126

Reaction notes

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