Acetamidomalonic acid diethyl ester → Diethyl acetamido-(6-methoxycarbonylhex-2-enyl)malonate

HRID 444050Notes

Reaction equation

HRID 444050 reaction equation
Br[CH2:2]/[CH:3]=[CH:4]\[CH2:5][CH2:6][CH2:7][C:8]([O:10][CH3:11])=[O:9].[C:12]([NH:15][CH:16]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:17]([O:19][CH2:20][CH3:21])=[O:18])(=[O:14])[CH3:13]>>[C:12]([NH:15][C:16]([CH2:2][CH:3]=[CH:4][CH2:5][CH2:6][CH2:7][C:8]([O:10][CH3:11])=[O:9])([C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:17]([O:19][CH2:20][CH3:21])=[O:18])(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 14041Acetamidomalonic acid diethyl esterHCID 11253002Methyl cis-7-bromo-5-heptenoate

Product 1

HCID 54210118Diethyl acetamido-(6-methoxycarbonylhex-2-enyl)malonate

Procedure

cis-Methyl 7-bromohept-5-enoate (prepared by the method of Brit. Pat. No. 1 355 991) and diethyl acetamidomalonate reacted under the conditions described in Example 1A to give diethyl acetamido-(6-methoxycarbonylhex-2-enyl)malonate as a yellow oil.

Sources & evidence

ORD record
ord-0ccc4513ab674b15b2dbe843ab3fd546
Source dataset
uspto-grants-1981_04
Patent number
US04262128

Reaction notes

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