HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 5-Cyano-2,3-dihydro-3,3-dimethylbenzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 5-Bromo-3,3-dimethyl-2,3-dihydro-1-benzofuran | HCID 5323595 | — |
| Product | 5-Cyano-2,3-dihydro-3,3-dimethylbenzofuran | HCID 20536190 | — |
Reaction Steps
5-Bromo-2,3-dihydro-3,3-dimethylbenzofuran (15 g, 0.066 mole) was heated under reflux with cuprous cyanide (7.2 g. 0.08 mole) in dimethyl formamide (15 ml) as in Example 2. Work up yielded, after recrystallisation from petroleum ether (bp 60°-80° C.) with charcoaling, 5.7 g of product, mp 72°-75° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04263037 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-ad44c049a2b543cba4bb3fed2272fe36 |
| Source note | uspto-grants-1981_04 |