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Diethyl Ether → 2-(2-Methoxy-5-cyanophenyl)-2-methyl-1-propanal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 2-(5-Bromo-2-methoxyphenyl)-2-methylpropanal | HCID 20536223 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(2-Methoxy-5-cyanophenyl)-2-methyl-1-propanal | HCID 20536256 | — |
反応手順
2-(2-Methoxy-5-bromophenyl)-2-methyl-1-propanal (9.5 g), prepared as in Example 5(d), cuprous cyanide (4.0 g) and dimethylformamide (20 ml) were heated under reflux with stirring for 3 hours. A solution of ferric chloride (7.3 g) in water (25 ml) and hydrochloric acid (3.5 ml conc) was added to the cooled reaction mixture which was then heated at 60°-70° C. for 5 minutes. Isolation of the product through diethyl ether yielded, after recrystallisation from ethanol, 3 g of pure product, mp 115°-117° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04263037 |
| 出典データセット | uspto-grants-1981_04 |
| ORD ID | ord-b065fcfa0a9444ab950354ce38f19a29 |
| 出典メモ | uspto-grants-1981_04 |