反应详情

A solution of the product of stage (c) (183 g) in ethanol (150 ml) was heated to reflux. A solution of sodium cyanide (25 g) in hot water (50 ml) was added which maintained gentle refluxing. The mixture was then stirred for 5 minutes, poured into ice water, and the product was filtered off, taken up in dichloromethane, washed with water, dried over magnesium sulphate and filtered. The solvent was removed to give a brown oil which slowly crystallised. Recrystallisation from petroleum ether gave the title product as colourless needles, mp 87°-88° C.

1. temperaturemaintained gentle refluxing
2. filtrationthe product was filtered off
3. washwashed with water
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. customThe solvent was removed
7. customto give a brown oil which
8. customslowly crystallised
9. customRecrystallisation from petroleum ether