反应详情

2-Chloro-5-cyano-2,3-dihydro-3,3-dimethylbenzofuran (4.1 g), prepared as in Example 45 was heated under reflux at about 130° C. in morpholine (20 ml) for 4 hours. Addition to ice-water, followed by extraction with diethyl ether, gave, after water washing, drying over sodium sulphate and running down, 3.3 g of crude title product. Recrystallisation from isopropanol gave 2.3 g of pure product, mp 105°-107° C.

1. temperaturewas heated
2. extractionfollowed by extraction with diethyl ether
3. customgave
4. dry with materialafter water washing, drying over sodium sulphate
5. customRecrystallisation from isopropanol