HCID 23464494, compound → HCID 13013942, compound

Participants

Reaction Steps

Stir at room temperature 795 mg of the ester of Example 26 in a mixture of 50 ml of 10% aqueous sodium hydroxide and 50 ml of tetrahydrofuran for 3 hours. Separate the layers and extract the organic layer with 10% aqueous sodium hydroxide. Wash the combined aqueous layers with ether and acidify with acetic acid. Separate the precipitate by filtration, wash with water and dry in order to obtain the title product (m.p. 337°-340° C. with subsequent dec.).

Provenance & Evidence