Sodium Hydroxide → Tofacitinib

Participants

Reaction Steps

The 3-{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile citrate salt, as prepared in Method F above, was treated with 1M sodium hydroxide in dichloromethane to afford the corresponding free base. The free base was then crystallized from methanol and water to furnish the crystal form of the free base.

Provenance & Evidence