反应详情

Heat a mixture of 5.0 gm. of 3-cyano-10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepin and 4.0 gm. of Raney nickel alloy in 60 ml. of 75% (v/v) aqueous formic acid at reflux for 1.5 hours. Cool to room temperature and filter. Concentrate to small volume and extract with methylene chloride. Wash the extract with water and with 1 N sodium bicarbonate until neutral. Dry the neutral extract over sodium sulfate and concentrate to dryness to obtain the title product.

1. temperatureHeat
2. additiona mixture of 5.0 gm
3. filtrationfilter
4. concentrationConcentrate to small volume
5. extractionextract with methylene chloride
6. washWash the
7. extractionextract with water and with 1 N sodium bicarbonate until neutral
8. customDry the
9. extractionneutral extract over sodium sulfate
10. concentrationconcentrate to dryness